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No documented copper toxicity occurs at recommended doses, with toxic thresholds 300-3,750 times higher than therapeutic ranges
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However, these effects did not remain significant after FDR correction and should be considered exploratory
After subcutaneous injection of CAF cell supernatant with miR-522 knockout into nude mice, the expression level of miR-522 decreased, the levels of ALOX15 and reactive oxygen species in tumor cells increased, the probability of ferroptosis in tumor cells increased, and the number of tumor cells decreased 147
Surprisingly, these phenotypic consequences of CBP/p300 inhibition did not result in viability defects in NRF2-dependent cell lines
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